Marbocyl 10%

Marbocyl 10%

Broad spectrum antibiotic: Gram+, Gram- and Mycoplasma. Low MIC. Quick bactericidal activity. Excellent tissular distribution


Solution for injection:
Marbofloxacin……………… 100.0 mg
Disodium edetate………………..0.1 mg
Thioglycerol……………………..1.0 mg
M-cresol…………………………2.0 mg
Excipient to…………………… 1 ml

Marbocyl 10%


Marbofloxacin is a bactericidal anti-infectious belonging to the fluoroquinolones group. It acts by inhibition of DNA-gyrase. Its spectrum is broad, directed towards Gram positive (especially Staphylococcus), Gram negative bacteria (Escherichia coli, Pasteurella spp.) and Mycoplasma (Mycoplasma bovis, Mycoplasma hyopneumoniae).
• Pharmacokinetic properties :
After subcutaneous or intramuscular administration at the recommended dose of 2 mg/kg in cattle and pigs, Marbofloxacin is rapidly absorbed and reaches maximal plasmatic concentrations of 1,5 µg/ml in less than one hour. The bioavailability is close to 100 %.
Marbofloxacin is slightly related to plasmatic proteins (less than 10 % in the pig and less than 30 % in cattle) and is widely distributed in the entire organism. In the majority of tissues (liver, kidney, skin, lung, uterus), tissular concentrations are higher than those of plasma.
Marbofloxacin is slowly eliminated in the pre-ruminant calf (t1/2 = 5-9 hours) and the pig (t1/2 = 8-10 hours), more rapidly in ruminant cattle (t1/2 = 4-7 hours), and mainly in active form in the urines and faeces.


Disorders caused by germs sensitive to Marbofloxacin.
In cattle : treatment of respiratory infections with strains sensitive to Pasteurella multocida, Pasteurella haemolytica and Mycoplasma bovis. Treatment of acute mastitis with strains sensitive to Escherichia Coli.
In sows : treatment of metritis-mastitis-agalactia with strains sensitive to Marbofloxacin.
Control the sensitivity of strains prior to use the product.

Marbocyl 10%

 Administration and dosage

• Cattle : IV, IM, SC administrations.
2 mg of Marbofloxacin per kg (i.e.1 ml for 50 kg of b.w.) in a daily injection by IM or SC route for 3 – 5 days. The first injection can also be carried out by IV administration.
However, in cattle, it has been shown that subcutaneous route was better tolerated than I.M. administration. It is thus recommended for adult cattle. Inject preferably on the neck.
• Sows : IM route.
2 mg of Marbofloxacin per kg (i.e. 1 ml for 50 kg of b.w.) in a daily injection for 3 days

 Special Warnings

• Use during pregnancy and lactation :
Studies in animals of laboratory (rat, rabbit) have not produced any evidence of a teratogenic, foetotoxic or maternotoxic effect of Marbofloxacin.
Harmlessness of the product has been shown in the pregnant cow.
During use of the product in the sow and the cow, harmlessness has been shown in piglets and suckling calves.
• Overdose :
No sign of overdose has been shown with the product after administration of 3 times the recommended dose.
In the case of overdose with Marbofloxacin, acute neurological signs occur whose treatment is symptomatic.

Marbocyl 10%


Do not administer in the case of resistant bacteria to other fluoroquinolones infections.

 Side effects

Administration by I.M. route may occur transitory local reactions such as pain or oedema at the site of injection, and inflammatory reactions, which persist for at least 12 days after injection.

 Withdrawal period

• Cattle :
– Meat and offal : 6 days.
– Milk : 3 milkings (36 hours).
• Sows :
– Meat and offal : 4 days.


List I.
Prescription only medicine. This drug should be stored during duration of its withdrawal period.

Marbocyl 10%

 Special precautions for storage

After opening, the bottle can be stored 1 month below 25° C.


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