Sodium Salicylate Injection is an anti-pyretic, anti-thrombotic non-steroidal anti-inflammatory drug (NSAID).
COMPOSITION: Contains: Sodium salicylate 250 mg/ml
ACTIONS: Sodium salicylate produces irreversible inhibition of the cyclo-oxygenase step of arachidonic acid metabolism, leading to a suppression of prostaglandin production in all metabolic systems. The duration of action allows a 12 hour dosage regime for inflammatory conditions. Thrombosis inhibition requires administration every 2-7 days, depending on the dose.
INDICATIONS: Sodium Salicylate Injection is indicated for the control of fever and/or pain, as well as for control of inappropriate thrombosis in the horse, greyhound, camel and dog.
Salicylate has a half-life of 1 hour in the horse and 8.5 hours in the dog, and is rapidly cleared from the body. Onset of action is approximately 10 – 15 minutes.
Sodium Salicylate Injection will not control severe visceral pain, or sharp or excruciating pain due to severe wounds or fractures.
Musculo-skeletal: Short term treatment of mild joint and connective tissue disease, osteoarthritis, tendon and ligament sprains and exertional myopathy.
Pyrexia: Symptomatic suppression of fever in situations where the pyrexia is inappropriate or excessive.
Thrombosis: Prevention or reduction of thrombosis when it plays a part in disease aetiology (such as pedal thrombotic conditions), early disseminated intravascular coagulation -DIC- in horses and as an adjunct to Dirofilaria immitis adulticide therapy in dogs.
DOSEAGE & ADMINISTRATION:
Anti-inflammatory Effect: Horse: 35 – 45 mg/kg every 8 – 12 hours by slow intravenous injection. Dogs: 10 mg/kg every 12 hours by slow intravenous injection.
Anti-thrombotic Effect: Horse: 5 mg/kg every second day, or 20 mg/kg every 5th day. Dogs: 3 mg/kg every 6 days
STORAGE: Store below 25°C (Air Conditioning).